The Single Shield Prize is structured across three stages, designed to advance vaccine candidates from concept to Investigational New Drug application.

Register for the September 9 informational webinar to hear an overview of the prize, scientific scope, and key details for potential entrants.

Stage 1: Nonclinical Proof of Concept

Stage 1 is anticipated to be open from Q2 2027 to mid-2029. Stage 1 is open to Concept Stage winners and new entrants who meet the eligibility requirements.

Declarations of Intent (DOIs)

New entrants must submit a DOI and be approved before they can submit a Stage 1 technical paper. Detailed requirements will be published prior to the launch of Stage 1.

Technical papers

Eligible entrants can submit technical papers detailing outcomes of completed Stage 1 activities. Technical papers can be submitted as soon as they are ready during the open submission window.

Stage 2: IND Readiness

Stage 2 represents the critical transition from research-grade proof of concept to regulatory-grade drug product ready for clinical investigation.

Stage 2 launches

Anticipated mid-2029
Stage 1 winners will be eligible for Stage 2.

Submission period ends

Anticipated mid-2031
Deadline for submissions.

Winner announcement and Demo Day

Anticipated late 2031
Winner(s) will be announced and may be invited to showcase their proposed vaccine candidate at a Demo Day event.